Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 10/20 | 0.63 |
| ▸ | MET | P08581 | 7/20 | 0.63 |
| ▸ | KDR | P35968 | 4/20 | 0.63 |
| ▸ | FLT3 | P36888 | 3/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.63 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.63 |
| ▸ | MST1R | Q04912 | 9/20 | 0.52 |
| ▸ | MERTK | Q12866 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | HCK | P08631 | 2/20 | 0.52 |
| ▸ | BCR | P11274 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | ABL2 | P42684 | 2/20 | 0.52 |
| ▸ | FRK | P42685 | 2/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105538 | 0.95 | MET (0.64) | AXLMETKDRFLT3NTRK1 | |
| SCHEMBL29514769 | 0.88 | MET (0.73) | AXLMETKDRFLT3NTRK1 | |
| SCHEMBL103903 | 0.88 | MET (0.73) | AXLMETKDRFLT3NTRK1 | |
| SCHEMBL104989 | 0.84 | MET (0.67) | AXLMETKDRFLT3NTRK1 | |
| SCHEMBL10202011 | 0.83 | AXL (0.78) | AXLMETKDRFLT3NTRK1 | |
| SCHEMBL2534615 | 0.82 | MET (0.65) | AXLMETKDRFLT3NTRK1 | |
| Malic Acid SCHEMBL29910932 | 0.82 | MET (0.65) | AXLMETKDRFLT3NTRK1 | |
| Malic Acid SCHEMBL29910999 | 0.82 | MET (0.65) | AXLMETKDRFLT3NTRK1 | |
| Malic Acid SCHEMBL26110839 | 0.82 | MET (0.65) | AXLMETKDRFLT3NTRK1 | |
| SCHEMBL2670680 | 0.82 | MET (0.64) | AXLMETKDRFLT3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183254-B1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC (CA) | 2017-06-21 | — | — | EP | disclosed |
| US-8846927-B2 | Inhibitors of protein tyrosine kinase activity | METHYLGENE INC. (CA) | 2014-09-30 | — | — | US | disclosed |
| US-20130165477-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC. (CA) | 2013-06-27 | — | — | US | disclosed |
| US-8389541-B2 | Inhibitors of protein tyrosine kinase activity | METHYLGENE INC. (CA) | 2013-03-05 | — | — | US | disclosed |
| US-20120108628-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | Mirati Therapeutics, Inc. | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165477-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | HGF, ERBB2, MET | AXL 130/4885MET 3/4885KDR 11/4885 |
| US-20120108628-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | HGF, ERBB2, MET | AXL 130/4885MET 3/4885KDR 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.