Pumafentrine

Pumafentrine

SCHEMBL26718

CCOc1cc2c(cc1OC)C(c1ccc(C(=O)N(C(C)C)C(C)C)cc1)=N[C@@H]1CCN(C)C[C@H]21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 2/20 1.00
PDE4A P27815 1/20 1.00
PDE4B Q07343 1/20 1.00
PDE4C Q08493 1/20 1.00
MCHR1 Q99705 3/20 0.36
CTSD P07339 1/20 0.34
HPGD P15428 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
ATM Q13315 1/20 0.33
ALDH1A1 P00352 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
KMT2A Q03164 2/20 0.33
MAPT P10636 2/20 0.33
KDM4E B2RXH2 1/20 0.33
LTB4R Q15722 1/20 0.33
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
SRD5A2 P31213 1/20 0.33
RAB9A P51151 1/20 0.32
HRH3 Q9Y5N1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pumafentrine SCHEMBL447418 1.00 PDE4D (1.00) PDE4DPDE4APDE4BPDE4CMCHR1
SCHEMBL7204721 1.00 PDE4D (1.00) PDE4DPDE4APDE4BPDE4CMCHR1
Pumafentrine SCHEMBL8344522 1.00 PDE4D (1.00) PDE4DPDE4APDE4BPDE4CMCHR1
Pumafentrine SCHEMBL29651667 1.00 PDE4D (1.00) PDE4DPDE4APDE4BPDE4CMCHR1
Pumafentrine SCHEMBL5187632 0.99 PDE4D (0.98) PDE4DPDE4APDE4BPDE4CMCHR1
Hydrochloric Acid SCHEMBL8388626 0.99 PDE4D (0.98) PDE4DPDE4APDE4BPDE4CMCHR1
Pumafentrine SCHEMBL5187638 0.99 PDE4D (0.98) PDE4DPDE4APDE4BPDE4CMCHR1
Hydrochloric Acid SCHEMBL8388627 0.99 PDE4D (0.98) PDE4DPDE4APDE4BPDE4CMCHR1
SCHEMBL7204406 0.97 PDE4D (0.94) PDE4DPDE4APDE4BPDE4CMCHR1
SCHEMBL7204724 0.97 PDE4D (0.94) PDE4DPDE4APDE4BPDE4CMCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2130 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol CELLIX BIO PRIVATE LIMITED (IN) 2024-02-20 US claimed
WO-2022190030-A1 A TOPICAL FORMULATION FOR THE TREATMENT OF SKIN DISEASES AVACA PHARMA PRIVATE LIMITED (IN) 2022-09-15 WO claimed
WO-2022157587-A1 A COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 WO claimed
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 US claimed
WO-2022123511-A1 A COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 WO claimed
US-20220184052-A1 COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 US claimed
US-20200237735-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A P13 DELTA OR DUAL P13 DELTA-GAMMA KINASE INHIBITOR RHIZEN PHARMACEUTICALS AG (CH) 2020-07-30 US claimed
EP-3621593-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES Cardix Therapeutics LLC (US) 2020-03-18 EP claimed
WO-2019194866-A1 DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES Cardix Therapeutics LLC (US) 2019-10-10 WO claimed
US-20190231786-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES CARDIX Therapeutics, LLC 2019-08-01 US claimed
WO-2003074055-A1 PHARMACEUTICAL COMPOSITION OF A PDE4 OR A PDE3/4 INHIBITOR AND A HISTAMINE RECEPTOR ANTAGONIST ALTANA PHARMA AG (DE) 2003-09-12 WO claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
US-20030104974-A1 Dual inhibitorsof PDE 7 and PDE 4 BRISTOL-MYERS SQUIBB COMPANY 2003-06-05 US claimed
WO-2003039552-A1 COMBINATION OF PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG ALTANA PHARMA AG (DE) 2003-05-15 WO claimed
US-20030092706-A1 Combination NYCOMED GMBH (DE) 2003-05-15 US claimed
WO-2003024488-A2 COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST ALTANA PHARMA AG (DE) 2003-03-27 WO claimed
EP-0937074-B1 BENZONAPHTHYRIDINES AS BRONCHIAL THERAPEUTICS ALTANA PHARMA AG (DE) 2003-03-12 EP claimed
WO-2002088079-A2 DUAL INHIBITORS OF PDE 7 AND PDE 4 BRISTOL-MYERS SQUIBB COMPANY (US) 2002-11-07 WO claimed
WO-2002088080-A2 DUAL INHIBITORS OF PDE 7 AND PDE 4 BRISTOL-MYERS SQUIBB COMPANY (US) 2002-11-07 WO claimed
US-6008215-A TREATING INFLAMMATORY AIRWAY DISORDERS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1999-12-28 US claimed