Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.94 |
| ▸ | PDE4A | P27815 | 3/20 | 0.94 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.94 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.94 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204406 | 1.00 | PDE4D (0.94) | PDE4DPDE4APDE4BPDE4CMCHR1 | |
| Hydrochloric Acid SCHEMBL7204757 | 0.99 | PDE4D (0.92) | PDE4DPDE4APDE4BPDE4CMCHR1 | |
| Pumafentrine SCHEMBL29651667 | 0.97 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CMCHR1 | |
| Pumafentrine SCHEMBL26718 | 0.97 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CMCHR1 | |
| Pumafentrine SCHEMBL8344522 | 0.97 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CMCHR1 | |
| Pumafentrine SCHEMBL447418 | 0.97 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CMCHR1 | |
| SCHEMBL7204721 | 0.97 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CMCHR1 | |
| Pumafentrine SCHEMBL5187632 | 0.96 | PDE4D (0.98) | PDE4DPDE4APDE4BPDE4CMCHR1 | |
| Pumafentrine SCHEMBL5187638 | 0.96 | PDE4D (0.98) | PDE4DPDE4APDE4BPDE4CMCHR1 | |
| Hydrochloric Acid SCHEMBL8388626 | 0.96 | PDE4D (0.98) | PDE4DPDE4APDE4BPDE4CMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937074-B1 | BENZONAPHTHYRIDINES AS BRONCHIAL THERAPEUTICS | ALTANA PHARMA AG (DE) | 2003-03-12 | — | — | EP | claimed |
| EP-0937074-B1 | BENZONAPHTHYRIDINES AS BRONCHIAL THERAPEUTICS | ALTANA PHARMA AG (DE) | 2003-03-12 | — | — | EP | disclosed |
| US-6008215-A | TREATING INFLAMMATORY AIRWAY DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1999-12-28 | — | — | US | disclosed |