SCHEMBL267529

SCHEMBL267529

COc1ccc(/C=N/NC(=O)c2c(NC(=O)c3cccc(CN(CC(C)O)CC(C)O)c3)sc3c2CCC3)cc1

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TP53 P04637 6/20 0.51
FLT3 P36888 2/20 0.50
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
NOD1 Q9Y239 1/20 0.49
SLC34A2 O95436 3/20 0.48
MGAM O43451 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
MAPT P10636 3/20 0.47
AMY1A P0DUB6 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46
THRB P10828 1/20 0.46
GLO1 Q04760 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL267530 1.00 TP53 (0.51) TP53FLT3MEN1KMT2ANOD1
SCHEMBL267351 0.99 TP53 (0.53) TP53FLT3MEN1KMT2ANOD1
SCHEMBL274222 0.99 TP53 (0.53) TP53FLT3MEN1KMT2ANOD1
SCHEMBL267495 0.92 SLC34A2 (0.50) TP53FLT3MEN1KMT2ASLC34A2
SCHEMBL267494 0.92 SLC34A2 (0.50) TP53FLT3MEN1KMT2ASLC34A2
SCHEMBL269538 0.91 SLC34A2 (0.51) TP53FLT3MEN1KMT2ASLC34A2
SCHEMBL269539 0.91 SLC34A2 (0.51) TP53FLT3MEN1KMT2ASLC34A2
SCHEMBL273826 0.91 SLC34A2 (0.52) TP53FLT3MEN1KMT2ASLC34A2
SCHEMBL267215 0.91 SLC34A2 (0.52) TP53FLT3MEN1KMT2ASLC34A2
SCHEMBL265629 0.90 SLC34A2 (0.53) TP53FLT3MEN1KMT2ASLC34A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 TP53 2556/4885FLT3 1555/4885MEN1 1194/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 TP53 2188/4885FLT3 2535/4885MEN1 1638/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.