Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24752581 | 0.83 | KCNJ5 (0.32) | — | |
| SCHEMBL26754925 | 0.81 | SCN9A (0.35) | LRRK2SCN9ACYP2C19MEN1CYP1A2 | |
| SCHEMBL14396802 | 0.81 | PDE4D (0.35) | CYP2C19MEN1CYP1A2KMT2ACYP2C9 | |
| SCHEMBL27405100 | 0.77 | SCN9A (0.42) | LRRK2SCN9AMEN1KMT2AMAT2A | |
| SCHEMBL26755473 | 0.75 | MAT2A (0.35) | SCN9ACYP2C19MEN1CYP1A2KMT2A | |
| SCHEMBL26861578 | 0.74 | LRRK2 (0.39) | LRRK2SCN9AMEN1CYP1A2KMT2A | |
| SCHEMBL12806686 | 0.73 | MAP3K5 (0.30) | CYP2C9KCNH2 | |
| SCHEMBL25159793 | 0.72 | ALDH1A1 (0.47) | CNR2LMNA | |
| SCHEMBL2737292 | 0.72 | GAA (0.38) | CYP2C19CYP1A2GAACYP2C9LMNA | |
| SCHEMBL23082903 | 0.69 | SCN9A (0.41) | LRRK2SCN9ACYP2C19CYP17A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217851-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF-κB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |