Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 4/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24878817 | 0.81 | POLB (0.46) | POLBBRD9CYP2C19NPC1KMT2A | |
| SCHEMBL14967583 | 0.80 | POLB (0.51) | POLBBRD9CYP2C19NPC1KMT2A | |
| SCHEMBL21785519 | 0.76 | MET (0.40) | POLBCYP2C19NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL18186597 | 0.73 | POLB (0.44) | POLBSMN1; SMN2METAXL | |
| SCHEMBL26756058 | 0.71 | KDM4E (0.44) | POLBSMN1; SMN2GSK3AGSK3BMAT2A | |
| SCHEMBL31728526 | 0.69 | BRD9 (0.59) | POLBBRD9CYP2C19NPC1KMT2A | |
| SCHEMBL14969327 | 0.68 | POLB (0.50) | POLBCYP2C19NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL26756417 | 0.68 | POLB (0.37) | POLBCYP2C19KMT2ASMN1; SMN2GSK3A | |
| SCHEMBL14970191 | 0.67 | NPC1 (0.55) | POLBCYP2C19NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL22349793 | 0.67 | PPARD (0.48) | POLBNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843850-B1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC (US) | 2023-11-15 | — | — | EP | disclosed |