Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | P2RY10 | O00398 | 4/20 | 0.38 |
| ▸ | GPR174 | Q9BXC1 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2677380 | 1.00 | HDAC1 (0.47) | HDAC1HDAC2CHRM1AKR1A1CHRM3 | |
| SCHEMBL2677376 | 1.00 | HDAC1 (0.47) | HDAC1HDAC2CHRM1AKR1A1CHRM3 | |
| SCHEMBL16301422 | 0.81 | HDAC1 (0.50) | HDAC1HDAC2CHRM1AKR1A1CHRM3 | |
| SCHEMBL3422700 | 0.79 | SLC1A2 (0.45) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| SCHEMBL6895084 | 0.79 | HDAC1 (0.44) | HDAC1HDAC2CHRM1AKR1A1CHRM3 | |
| Hydrochloric Acid SCHEMBL3508612 | 0.77 | HDAC1 (0.43) | HDAC1HDAC2CHRM1AKR1A1CHRM3 | |
| SCHEMBL10241658 | 0.77 | CA1 (0.50) | HDAC1HDAC2SLC6A3TDP1SLC1A2 | |
| SCHEMBL23286474 | 0.77 | SLC7A5 (0.48) | SLC1A2SLC1A1SLC1A3SLC7A5P2RY10 | |
| SCHEMBL1514131 | 0.77 | SLC7A5 (0.48) | SLC1A2SLC1A1SLC1A3SLC7A5P2RY10 | |
| SCHEMBL1811512 | 0.77 | SLC7A5 (0.48) | SLC1A2SLC1A1SLC1A3SLC7A5P2RY10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173840-B2 | Compounds with high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-08 | — | — | US | disclosed |
| US-20060241017-A1 | Novel compounds with high therapeutic index | SIGNATURE R&D HOLDINGS, LLC | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241017-A1 | Novel compounds with high therapeutic index | IL4I1, SLC7A1, GOT1 | HDAC1 864/4885HDAC2 1383/4885CHRM1 4177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.