Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 9/20 | 0.44 |
| ▸ | IDO1 | P14902 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26783436 | 0.87 | IDO1 (0.44) | HCRTR1IDO1SMN1; SMN2LMNAHCRTR2 | |
| SCHEMBL26783502 | 0.83 | IDO1 (0.44) | IDO1SMN1; SMN2 | |
| SCHEMBL23271191 | 0.82 | IDO1 (0.60) | HCRTR1IDO1SMN1; SMN2LMNATDO2 | |
| SCHEMBL29639861 | 0.82 | IDO1 (0.60) | HCRTR1IDO1SMN1; SMN2LMNATDO2 | |
| SCHEMBL26783412 | 0.75 | IDO1 (0.42) | IDO1SMN1; SMN2 | |
| SCHEMBL21504261 | 0.74 | IDO1 (0.48) | IDO1SMN1; SMN2 | |
| SCHEMBL24117976 | 0.72 | IDO1 (0.45) | IDO1SMN1; SMN2LMNA | |
| SCHEMBL23572590 | 0.71 | IDO1 (0.56) | IDO1SMN1; SMN2LMNA | |
| SCHEMBL29639839 | 0.71 | IDO1 (0.56) | IDO1SMN1; SMN2LMNA | |
| SCHEMBL21504253 | 0.71 | IDO1 (0.55) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810116-B1 | NOVEL SUBSTITUTED [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-11-15 | — | — | EP | disclosed |