Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 12/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26783399 | 0.83 | HCRTR1 (0.44) | IDO1SMN1; SMN2 | |
| SCHEMBL26783436 | 0.82 | IDO1 (0.44) | IDO1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23271183 | 0.82 | IDO1 (0.61) | IDO1MAPTRECQLMEN1CYP1A2 | |
| SCHEMBL26783412 | 0.78 | IDO1 (0.42) | IDO1MAPTRECQLMEN1CYP1A2 | |
| SCHEMBL26783751 | 0.73 | IDO1 (0.55) | IDO1MAPTRECQLMEN1CYP1A2 | |
| SCHEMBL21504253 | 0.73 | IDO1 (0.55) | IDO1MAPTRECQLMEN1CYP1A2 | |
| SCHEMBL21504150 | 0.73 | IDO1 (0.65) | IDO1MAPTRECQLMEN1CYP1A2 | |
| SCHEMBL24117976 | 0.73 | IDO1 (0.45) | IDO1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21504261 | 0.71 | IDO1 (0.48) | IDO1MEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23572589 | 0.70 | IDO1 (0.61) | IDO1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810116-B1 | NOVEL SUBSTITUTED [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-11-15 | — | — | EP | disclosed |