SCHEMBL267837

SCHEMBL267837

CC1CCN(c2ccc(NC(=O)c3cccc(CSCCO)c3)c(C(=O)NN=Cc3ccc(Cl)c(C(F)(F)F)c3)c2)CC1

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 12/20 0.47
SLC34A1 Q06495 1/20 0.47
SLC34A3 Q8N130 1/20 0.47
SLC20A1 Q8WUM9 1/20 0.47
ADCYAP1R1 P41586 3/20 0.34
NOTUM Q6P988 3/20 0.34
RAF1 P04049 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL267836 1.00 SLC34A2 (0.47) SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1
SCHEMBL274085 1.00 SLC34A2 (0.47) SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1
SCHEMBL274494 0.94 SLC34A2 (0.52) SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1
SCHEMBL269720 0.94 SLC34A2 (0.52) SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1
SCHEMBL269721 0.94 SLC34A2 (0.52) SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1
SCHEMBL274880 0.94 SLC34A2 (0.47) SLC34A2SLC34A1SLC34A3SLC20A1NOTUM
SCHEMBL267029 0.94 SLC34A2 (0.47) SLC34A2SLC34A1SLC34A3SLC20A1NOTUM
SCHEMBL267028 0.94 SLC34A2 (0.47) SLC34A2SLC34A1SLC34A3SLC20A1NOTUM
SCHEMBL266437 0.93 SLC34A2 (0.49) SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1
SCHEMBL274508 0.93 SLC34A2 (0.49) SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885SLC34A1 4/4885SLC34A3 12/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885SLC34A1 1/4885SLC34A3 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.