Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.70 |
| ▸ | CA12 | O43570 | 6/20 | 0.64 |
| ▸ | CA1 | P00915 | 6/20 | 0.64 |
| ▸ | CA2 | P00918 | 6/20 | 0.64 |
| ▸ | CA9 | Q16790 | 6/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | IDE | P14735 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | HLCS | P50747 | 3/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.56 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10140274 | 0.99 | TDP1 (0.72) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL10000338 | 0.99 | TDP1 (0.72) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL3256514 | 0.99 | TDP1 (0.72) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL25014977 | 0.99 | TDP1 (0.72) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL30821562 | 0.99 | TDP1 (0.72) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL24420141 | 0.99 | TDP1 (0.72) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL15895090 | 0.99 | TDP1 (0.72) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL26598596 | 0.99 | TDP1 (0.72) | TDP1CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL8147632 | 0.98 | TDP1 (0.70) | TDP1CA12CA1CA2CA9 | |
| Ethylenediamine SCHEMBL16679417 | 0.98 | TDP1 (0.70) | TDP1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4646595-A1 | PEPTIDE SEQUENCER | Oregon Health & Science University (US) | 2025-11-12 | — | — | EP | disclosed |
| EP-3430015-B1 | METHODS TO DETERMINE KDM1A TARGET ENGAGEMENT AND CHEMOPROBES USEFUL THEREFOR | ORYZON GENOMICS SA (ES) | 2025-08-06 | — | — | EP | disclosed |
| US-12195783-B2 | Methods to determine KDM1A target engagement and chemoprobes useful therefor | ORYZON GENOMICS S.A. (ES) | 2025-01-14 | — | — | US | disclosed |
| WO-2024148174-A1 | PEPTIDE SEQUENCER | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |
| US-20220389478-A1 | METHODS TO DETERMINE KDM1A TARGET ENGAGEMENT AND CHEMOPROBES USEFUL THEREFOR | ORYZON GENOMICS SA (ES) | 2022-12-08 | — | — | US | disclosed |
| US-20220120739-A1 | CHIPS, DETECTORS, AND METHODS OF MAKING AND USING THE SAME | SENTILUS HOLDCO, LLC | 2022-04-21 | — | — | US | disclosed |
| EP-3245514-B1 | MACROMOLECULAR CONJUGATES FOR VISUALIZATION AND SEPARATION OF PROTEINS AND CELLS | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2019-07-10 | — | — | EP | disclosed |
| US-10302632-B2 | Macromolecular conjugates for visualization and separation of proteins and cells | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2019-05-28 | — | — | US | disclosed |
| US-20190033300-A1 | MACROMOLECULAR CONJUGATES FOR VISUALIZATION AND SEPARATION OF PROTEINS AND CELLS | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2019-01-31 | — | — | US | disclosed |
| US-20180052152-A1 | MACROMOLECULAR CONJUGATES FOR VISUALIZATION AND SEPARATION OF PROTEINS AND CELLS | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2018-02-22 | — | — | US | disclosed |
| EP-1084269-A4 | NOVEL PEROXIDASE SUBSTRATES AND THEIR USE IN CATALYZED REPORTER DEPOSITION | NEN LIFE SCIENCE PROD INC (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2004074935-A1 | MICROPATTERNING OF MOLECULAR SURFACES VIA SELECTIVE IRRADIATION | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2004-09-02 | — | — | WO | disclosed |
| EP-1314981-A2 | Benzo[c,d]indole-fluorochromes for labelling biomolecules and polymer particles | Chromeon GmbH (DE) | 2003-05-28 | — | — | EP | disclosed |
| EP-1084269-A1 | NOVEL PEROXIDASE SUBSTRATES AND THEIR USE IN CATALYZED REPORTER DEPOSITION | NEN Life Science Products, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063108-A1 | NOVEL PEROXIDASE SUBSTRATES AND THEIR USE IN CATALYZED REPORTER DEPOSITION | NEN LIFE SCIENCE PRODUCTS, INC. (US) | 1999-12-09 | — | — | WO | disclosed |
| US-5945527-A | REACTING CYTOSINE CONTAINING A LEAVING GROUP ATTACHED TO 5- OR 6-POSTION OF MOLECULE, ISOLATING MODIFIED NUCLEOSIDE; FOR NOVEL FUNGICIDES, VIRICIDES, BACTERICIDES, ANTITUMOR AGENTS | NEXSTAR PHARMACEUTICALS, INC. (US) | 1999-08-31 | — | — | US | disclosed |
| US-5863748-A | p-Hydroxycinnamoyl-containing substrates for an analyte dependent enzyme activation system | NEW LIFE SCIENCE PRODUCTS, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| EP-0828750-A1 | PALLADIUM CATALYZED NUCLEOSIDE MODIFICATION METHODS USING NUCLEOPHILES AND CARBON MONOXIDE | NeXstar Pharmaceuticals, Inc. (US) | 1998-03-18 | — | — | EP | disclosed |
| US-5719273-A | GENETIC ENGINEERING | NEXSTAR PHARMACEUTICALS, INC. (US) | 1998-02-17 | — | — | US | disclosed |
| WO-1996038460-A1 | PALLADIUM CATALYZED NUCLEOSIDE MODIFICATION METHODS USING NUCLEOPHILES AND CARBON MONOXIDE | NEXSTAR PHARMACEUTICALS, INC. (US) | 1996-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389478-A1 | METHODS TO DETERMINE KDM1A TARGET ENGAGEMENT AND CHEMOPROBES USEFUL THEREFOR | KDM1B, KDM1A, KDM7A | TDP1 1918/4885CA12 2752/4885CA1 1658/4885 |
| US-10302632-B2 | Macromolecular conjugates for visualization and separation of proteins and cells | RPS27A, CLTB, MSN | TDP1 2682/4885CA12 3046/4885CA1 3569/4885 |
| US-20180052152-A1 | MACROMOLECULAR CONJUGATES FOR VISUALIZATION AND SEPARATION OF PROTEINS AND CELLS | RPS27A, MSN, NAPA | TDP1 2968/4885CA12 2807/4885CA1 3472/4885 |
| US-20190033300-A1 | MACROMOLECULAR CONJUGATES FOR VISUALIZATION AND SEPARATION OF PROTEINS AND CELLS | RPS27A, CLTB, MSN | TDP1 2682/4885CA12 3046/4885CA1 3569/4885 |
| US-12195783-B2 | Methods to determine KDM1A target engagement and chemoprobes useful therefor | KDM1B, KDM1A, KDM7A | TDP1 1918/4885CA12 2752/4885CA1 1658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.