Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB2 | P29323 | 2/20 | 0.65 |
| ▸ | ABL1 | P00519 | 9/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.63 |
| ▸ | HCK | P08631 | 2/20 | 0.61 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.60 |
| ▸ | BCR | P11274 | 5/20 | 0.60 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.60 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.60 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078661 | 1.00 | EPHB2 (0.65) | EPHB2ABL1SRCHCKNR2C2 | |
| SCHEMBL2679133 | 0.92 | ABL1 (0.69) | EPHB2ABL1SRCHCKNR2C2 | |
| SCHEMBL2679307 | 0.87 | KIT (0.62) | EPHB2ABL1SRCHCKNR2C2 | |
| SCHEMBL2679904 | 0.85 | BRAF (0.49) | EPHB2ABL1SRCHCKNR2C2 | |
| SCHEMBL10077762 | 0.85 | BRAF (0.49) | EPHB2ABL1SRCHCKNR2C2 | |
| SCHEMBL28382296 | 0.83 | EPHB2 (0.77) | EPHB2ABL1SRCHCKNR2C2 | |
| SCHEMBL30546751 | 0.83 | EPHB2 (0.77) | EPHB2ABL1SRCHCKNR2C2 | |
| SCHEMBL22065195 | 0.83 | EPHB2 (0.75) | EPHB2ABL1SRCHCKNR2C2 | |
| SCHEMBL16867179 | 0.82 | EPHB2 (0.74) | EPHB2ABL1SRCHCKNR2C2 | |
| SCHEMBL30546654 | 0.82 | EPHB2 (0.74) | EPHB2ABL1SRCHCKNR2C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426446-B2 | Acrylamide derivative and use thereof in manufacture of medicament | BEIJING SHIQIAO BIOPHARM CO. LTD. (CN) | 2013-04-23 | — | — | US | claimed |
| US-20120116075-A1 | Acrylamide Derivative And Use Thereof In Manufacture Of Medicament | BEIJING JIASHILIANBO PHARM SCI & TECH CO. LTD | 2012-05-10 | — | — | US | claimed |
| US-8426446-B2 | Acrylamide derivative and use thereof in manufacture of medicament | BEIJING SHIQIAO BIOPHARM CO. LTD. (CN) | 2013-04-23 | — | — | US | disclosed |
| US-20120116075-A1 | Acrylamide Derivative And Use Thereof In Manufacture Of Medicament | BEIJING JIASHILIANBO PHARM SCI & TECH CO. LTD | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120116075-A1 | Acrylamide Derivative And Use Thereof In Manufacture Of Medicament | ABL1, ABL2, BCR | EPHB2 2694/4885ABL1 1/4885SRC 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.