Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 6/20 | 0.51 |
| ▸ | F2 | P00734 | 13/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.47 |
| ▸ | F7 | P08709 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25262638 | 0.94 | PSMB5 (0.51) | PSMB5F2PSEN1PSEN2APH1B | |
| SCHEMBL25262640 | 0.94 | PSMB5 (0.51) | PSMB5F2PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL25220096 | 0.93 | PSMB5 (0.51) | PSMB5F2PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL25268499 | 0.93 | PSMB5 (0.51) | PSMB5F2PSEN1PSEN2APH1B | |
| SCHEMBL21529960 | 0.89 | PSMB5 (0.56) | PSMB5F2PSEN1PSEN2APH1B | |
| SCHEMBL21529957 | 0.89 | PSMB5 (0.56) | PSMB5F2PSEN1PSEN2APH1B | |
| SCHEMBL22388146 | 0.89 | PSMB5 (0.56) | PSMB5F2PSEN1PSEN2APH1B | |
| SCHEMBL20628029 | 0.89 | PSMB5 (0.56) | PSMB5F2PSEN1PSEN2APH1B | |
| SCHEMBL22387966 | 0.89 | PSMB5 (0.56) | PSMB5F2PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL20399472 | 0.88 | PSMB5 (0.55) | PSMB5F2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827656-B2 | Immunoproteasome inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2023-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827656-B2 | Immunoproteasome inhibitors | PSMC2, PSMB7, PSMB2 | PSMB5 15/4885F2 4058/4885PSEN1 419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.