Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.48 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.44 |
| ▸ | PIK3C2B | O00750 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28321312 | 0.88 | KDM4E (0.46) | PARP1PARP2PARP3ALDH1A1KDM4E | |
| SCHEMBL4742353 | 0.85 | PARP1 (0.44) | PARP1PARP2PARP3ALDH1A1KDM4E | |
| SCHEMBL20357333 | 0.85 | CHRM3 (0.51) | PARP1PARP2ALDH1A1KDM4E | |
| SCHEMBL28847349 | 0.85 | KDM4E (0.49) | PARP1PARP2PARP3ALDH1A1KDM4E | |
| SCHEMBL19760571 | 0.80 | CYP2A13 (0.50) | ALDH1A1KDM4ECYP2A13PIK3C2BMEN1 | |
| SCHEMBL4714644 | 0.77 | FAAH (0.50) | PARP1FAAHPIK3C2BAKR1C3PIK3CD | |
| SCHEMBL16655571 | 0.77 | ALDH1A1 (0.50) | PARP1PARP2PARP3ALDH1A1KDM4E | |
| SCHEMBL18040375 | 0.75 | PARP1 (0.57) | PARP1PARP2PARP3ALDH1A1KDM4E | |
| SCHEMBL29832438 | 0.75 | PDE3B (0.51) | PARP1ALDH1A1KDM4ESCN9A | |
| SCHEMBL19760570 | 0.74 | KCNJ1 (0.46) | ALDH1A1CYP2A13MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110291081-A | BENZIMIDAZOLE COMPOUNDS AS C-KIT INHIBITORS | 阿瑞雅德制药公司 | 2019-09-27 | — | — | CN | claimed |
| US-8426446-B2 | Acrylamide derivative and use thereof in manufacture of medicament | BEIJING SHIQIAO BIOPHARM CO. LTD. (CN) | 2013-04-23 | — | — | US | disclosed |
| US-20120116075-A1 | Acrylamide Derivative And Use Thereof In Manufacture Of Medicament | BEIJING JIASHILIANBO PHARM SCI & TECH CO. LTD | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120116075-A1 | Acrylamide Derivative And Use Thereof In Manufacture Of Medicament | ABL1, ABL2, BCR | PARP1 4101/4885PARP2 3393/4885PARP3 1922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.