Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 11/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.35 |
| ▸ | CDK2 | P24941 | 8/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.35 |
| ▸ | CDK1 | P06493 | 6/20 | 0.35 |
| ▸ | CDK4 | P11802 | 6/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.35 |
| ▸ | CCND1 | P24385 | 6/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.35 |
| ▸ | CDK3 | Q00526 | 6/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.35 |
| ▸ | CDK7 | P50613 | 5/20 | 0.34 |
| ▸ | CCNH | P51946 | 4/20 | 0.34 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680006 | 1.00 | PDE10A (0.37) | PDE10ACDK9CCNT1CDK2CCNA1 | |
| SCHEMBL1072955 | 0.89 | DGAT1 (0.37) | PDE10ACDK9CCNT1CDK2CCNA1 | |
| SCHEMBL7883324 | 0.89 | DGAT1 (0.37) | PDE10ACDK9CCNT1CDK2CCNA1 | |
| SCHEMBL10237583 | 0.89 | PBK (0.36) | PDE10ACDK9CCNT1CDK2CCNA1 | |
| SCHEMBL7878598 | 0.89 | PBK (0.36) | PDE10ACDK9CCNT1CDK2CCNA1 | |
| SCHEMBL7880391 | 0.89 | PBK (0.36) | PDE10ACDK9CCNT1CDK2CCNA1 | |
| SCHEMBL2725294 | 0.88 | PDE4D (0.36) | PDE10ACDK9CCNT1CDK2CCNA1 | |
| SCHEMBL10280539 | 0.88 | PDE10A (0.38) | PDE10ACDK9CCNT1CDK2CCNA1 | |
| SCHEMBL10280538 | 0.88 | PDE10A (0.38) | PDE10ACDK9CCNT1CDK2CCNA1 | |
| SCHEMBL7875032 | 0.85 | CDK9 (0.34) | PDE10ACDK9CCNT1CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8591943-B2 | Pyrazolo[1,5-a]pyrimidine derivatives as mTOR inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-11-26 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | PDE10A 3001/4885CDK9 299/4885CCNT1 2200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.