Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | GUSB | P08236 | 3/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 6/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26807780 | 0.93 | LTA4H (0.47) | HTR6GUSBRIPK2ACVR1NOD2 | |
| SCHEMBL26807760 | 0.92 | LTA4H (0.48) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL26807765 | 0.92 | ACVR1 (0.39) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL26807773 | 0.91 | RIPK2 (0.43) | HTR6GUSBRIPK2ACVR1NOD2 | |
| SCHEMBL24309513 | 0.91 | LTA4H (0.41) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL29567157 | 0.91 | LTA4H (0.41) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL26807471 | 0.89 | ACVR1 (0.40) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL26807728 | 0.89 | FLT3 (0.37) | HTR6GUSBRIPK2ACVR1NOD2 | |
| SCHEMBL26807463 | 0.89 | ACVR1 (0.40) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL26807769 | 0.88 | GUSB (0.43) | HTR3EHTR3BADRB1HTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | HTR3E 2661/4885HTR3B 2729/4885ADRB1 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.