Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | GUSB | P08236 | 3/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309513 | 1.00 | LTA4H (0.41) | LTA4HHTR6GUSBNMT1PLA2G7 | |
| SCHEMBL26807760 | 0.94 | LTA4H (0.48) | LTA4HHTR6GUSBNMT1PLA2G7 | |
| SCHEMBL26807778 | 0.91 | HTR3E (0.46) | HTR6GUSBRIPK2ACVR1NOD2 | |
| SCHEMBL26807780 | 0.91 | LTA4H (0.47) | LTA4HHTR6GUSBRIPK2ACVR1 | |
| SCHEMBL29566336 | 0.91 | DGAT2 (0.42) | HTR6EGFR | |
| SCHEMBL24309631 | 0.91 | DGAT2 (0.42) | HTR6EGFR | |
| SCHEMBL26807769 | 0.90 | GUSB (0.43) | LTA4HHTR6GUSBHTR3EHTR3B | |
| SCHEMBL26807751 | 0.89 | GUSB (0.41) | LTA4HHTR6GUSBNMT1PLA2G7 | |
| SCHEMBL26807480 | 0.89 | LTA4H (0.43) | LTA4HHTR6GUSBNMT1RIPK2 | |
| SCHEMBL26807468 | 0.87 | GUSB (0.42) | LTA4HHTR6GUSBNMT1PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |