Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 12/20 | 0.39 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.39 |
| ▸ | NUAK2 | Q9H093 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | BLK | P51451 | 2/20 | 0.38 |
| ▸ | BMX | P51813 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | CTSC | P53634 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567464 | 1.00 | HTR1A (0.41) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL24309381 | 0.92 | HTR7 (0.42) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL29567219 | 0.92 | HTR7 (0.42) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL24310422 | 0.92 | PDE2A (0.40) | RAD52EGFRJAK2BLKBMX | |
| SCHEMBL29567000 | 0.92 | PDE2A (0.40) | RAD52EGFRJAK2BLKBMX | |
| SCHEMBL26808712 | 0.91 | HTR7 (0.41) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL24310431 | 0.91 | HTR2C (0.41) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL29566298 | 0.91 | HTR2C (0.41) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL26811481 | 0.90 | HTR2C (0.40) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL24310151 | 0.89 | HTR1A (0.40) | HTR1AHTR2AHTR2CHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | HTR1A 4018/4885HTR2A 3630/4885HTR2C 4185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.