Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.75 |
| ▸ | PKM | P14618 | 4/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19036159 | 0.86 | PKM (0.83) | HCRTR1PKMALDH1A1MAPTHTT | |
| SCHEMBL2704273 | 0.85 | PKM (0.78) | HCRTR1PKMALDH1A1MAPTHTT | |
| SCHEMBL2702167 | 0.85 | PKM (0.82) | HCRTR1PKMALDH1A1MAPTHTT | |
| SCHEMBL12964838 | 0.85 | PKM (1.00) | HCRTR1PKMALDH1A1MAPTHTT | |
| SCHEMBL2703016 | 0.85 | ALDH1A1 (0.86) | HCRTR1PKMALDH1A1MAPTHTT | |
| SCHEMBL12976972 | 0.85 | ALDH1A1 (0.86) | HCRTR1PKMALDH1A1MAPTHTT | |
| SCHEMBL10008458 | 0.85 | HCRTR1 (0.73) | HCRTR1PKMALDH1A1MAPTHTT | |
| SCHEMBL2702638 | 0.83 | PKM (0.84) | HCRTR1PKMALDH1A1MAPTHTT | |
| SCHEMBL2703621 | 0.83 | ALDH1A1 (0.74) | HCRTR1PKMALDH1A1MAPTHTT | |
| SCHEMBL12235 | 0.82 | PKM (0.60) | HCRTR1PKMALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3406251-B1 | PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY | AGIOS PHARMACEUTICALS INC (US) | 2023-11-29 | — | — | EP | disclosed |