Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20341751 | 0.83 | HSD17B1 (0.44) | NPC1RAB9AFFAR4NFKB1NFKB2 | |
| SCHEMBL8632736 | 0.80 | PARP1 (0.50) | NPC1RAB9ACYP11B1CYP11B2NFKB1 | |
| SCHEMBL20099201 | 0.79 | BACE1 (0.45) | NPC1RAB9ATDP2NPY5R | |
| SCHEMBL31593929 | 0.78 | NPC1 (0.52) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL798296 | 0.78 | NPC1 (0.52) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL24286750 | 0.78 | PARP10 (0.42) | NPC1RAB9ATDP2NPY5RTP53 | |
| SCHEMBL8635352 | 0.76 | PARP1 (0.50) | NPC1RAB9ACYP11B1CYP11B2NFKB1 | |
| Ethane SCHEMBL28782548 | 0.74 | NPC1 (0.49) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL5245075 | 0.74 | NPC1 (0.47) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL30634164 | 0.74 | NPC1 (0.47) | NPC1RAB9ANFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225162-A1 | ANTIVIRAL INDOLINYL COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2023-11-23 | — | — | WO | disclosed |