SCHEMBL8632736

SCHEMBL8632736

Fc1ccccc1-c1ccc2c(c1)CCC2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.50
PARP2 Q9UGN5 1/20 0.50
ADORA1 P30542 1/20 0.49
PTPRC P08575 1/20 0.47
PTPN1 P18031 1/20 0.47
HRH3 Q9Y5N1 1/20 0.47
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
TP53 P04637 1/20 0.44
MAPT P10636 1/20 0.44
NFKB1 P19838 1/20 0.44
HTT P42858 1/20 0.44
NFKB2 Q00653 1/20 0.44
RELA Q04206 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
PDK2 Q15119 1/20 0.44
ACMSD Q8TDX5 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
BACE1 P56817 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8635352 0.96 PARP1 (0.50) PARP1PARP2ADORA1PTPRCPTPN1
SCHEMBL7504001 0.82 MAOA (0.56) PARP1PARP2ADORA1PTPRCPTPN1
SCHEMBL8635876 0.82 HSD17B1 (0.56) PARP1PARP2PTPRCPTPN1HRH3
SCHEMBL26813630 0.80 NPC1 (0.41) PARP1HRH3NPC1RAB9ATP53
SCHEMBL18554655 0.78 CD274 (0.53) PARP1PARP2ADORA1
SCHEMBL8635759 0.78 PTPRC (0.53) PARP1PARP2ADORA1PTPRCPTPN1
SCHEMBL8072264 0.78 HRH3 (0.54) PARP1PARP2ADORA1PTPRCPTPN1
SCHEMBL27663193 0.78 ESR2 (0.49) NPC1RAB9ATP53NFKB1HTT
SCHEMBL20341751 0.77 HSD17B1 (0.44) NPC1RAB9ATP53MAPTNFKB1
SCHEMBL24287001 0.77 PARP1 (0.44) PARP1PARP2ADORA1PTPRCPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0601191-B1 NOVEL TETRACYCLIC COMPOUND KYOWA HAKKO KOGYO KK (JP) 1998-07-22 EP disclosed
US-5371225-A Immunosuppressants KYOWA HAKKO KOGYO CO., LTD. (JP) 1994-12-06 US disclosed
EP-0601191-A1 NOVEL TETRACYCLIC COMPOUND KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1994-06-15 EP disclosed