Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.56 |
| ▸ | SORD | Q00796 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | DKK1 | O94907 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13384572 | 0.86 | ACHE (0.53) | ACHESORDNR1H2NR1H3DKK1 | |
| SCHEMBL24126288 | 0.83 | ACHE (0.57) | ACHESORDKDM4EALDH1A1HPGD | |
| SCHEMBL15341840 | 0.82 | DYRK1A (0.43) | ACHESORDNR1H2NR1H3DKK1 | |
| SCHEMBL26141097 | 0.82 | SORD (0.47) | ACHESORDNR1H2NR1H3KDM4E | |
| SCHEMBL13384562 | 0.82 | SORD (0.47) | ACHESORDNR1H2NR1H3CDK2 | |
| SCHEMBL13384586 | 0.81 | SORD (0.46) | ACHESORDNR1H2NR1H3ALDH1A1 | |
| SCHEMBL26684341 | 0.81 | ACHE (0.55) | ACHESORDDKK1KDM4EALDH1A1 | |
| SCHEMBL15341852 | 0.81 | ACHE (0.47) | ACHESORDNR1H2NR1H3 | |
| SCHEMBL26141083 | 0.81 | DYRK1A (0.49) | ACHESORDNR1H2NR1H3HRH4 | |
| SCHEMBL17148516 | 0.81 | DYRK1A (0.47) | ACHESORDNR1H2NR1H3DKK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220137-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220129-A1 | BENZOYPARAZINE PYRAZINES ANE THEIR USES | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |