SCHEMBL268192

SCHEMBL268192

Cc1csc(NC(=O)c2cccc(C(S)c3nc[nH]n3)c2)c1C(=O)N/N=C\c1ccc(Cl)c(C(F)(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 11/20 0.44
MAPT P10636 5/20 0.34
RAB9A P51151 3/20 0.34
LMNA P02545 2/20 0.34
GAA P10253 1/20 0.34
POLB P06746 4/20 0.34
NPC1 O15118 2/20 0.34
NFKB1 P19838 1/20 0.34
NFKB2 Q00653 1/20 0.34
RELA Q04206 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ADCYAP1R1 P41586 2/20 0.33
ALDH1A1 P00352 1/20 0.33
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL268098 0.88 CTDSP1 (0.37) MAPTRAB9ALMNAPOLBNPC1
SCHEMBL268493 0.88 RAB9A (0.44) MAPTRAB9ALMNAGAAPOLB
SCHEMBL270113 0.87 NPC1 (0.42) MAPTRAB9ALMNAGAANPC1
SCHEMBL269451 0.87 GUSB (0.41) MAPTRAB9APOLBNPC1NFKB1
SCHEMBL267434 0.85 MAPT (0.42) MAPTRAB9AGAAPOLBNPC1
SCHEMBL266176 0.83 SLC34A2 (0.37) SLC34A2MAPTRAB9APOLBNPC1
SCHEMBL266941 0.83 SLC34A2 (0.43) SLC34A2MAPTRAB9ALMNANPC1
SCHEMBL268193 0.83 SLC34A2 (0.48) SLC34A2MAPTSMN1; SMN2ADCYAP1R1ALDH1A1
SCHEMBL273734 0.83 SLC34A2 (0.48) SLC34A2MAPTSMN1; SMN2ADCYAP1R1ALDH1A1
SCHEMBL266125 0.79 HPGD (0.39) MAPTRAB9ALMNAGAAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885MAPT 4195/4885RAB9A 883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.