SCHEMBL268257

SCHEMBL268257

O=C(Nc1cscc1C(=O)NN=Cc1ccc(Cl)c(C(F)(F)F)c1)c1cccc(CN2CCN(CCO)CC2)c1

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 12/20 0.56
ENPP2 Q13822 3/20 0.41
FAAH O00519 1/20 0.39
SLC34A1 Q06495 1/20 0.39
SLC34A3 Q8N130 1/20 0.39
SLC20A1 Q8WUM9 1/20 0.39
CSF1R P07333 1/20 0.38
KIT P10721 1/20 0.38
HDAC1 Q13547 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL274139 1.00 SLC34A2 (0.56) SLC34A2ENPP2FAAHSLC34A1SLC34A3
SCHEMBL268256 1.00 SLC34A2 (0.56) SLC34A2ENPP2FAAHSLC34A1SLC34A3
SCHEMBL269411 0.89 SLC34A2 (0.54) SLC34A2ENPP2FAAHSLC34A1SLC34A3
SCHEMBL274101 0.89 SLC34A2 (0.54) SLC34A2ENPP2FAAHSLC34A1SLC34A3
SCHEMBL269410 0.89 SLC34A2 (0.54) SLC34A2ENPP2FAAHSLC34A1SLC34A3
SCHEMBL267947 0.86 SLC34A2 (0.48) SLC34A2ENPP2SLC34A1SLC34A3SLC20A1
SCHEMBL267946 0.86 SLC34A2 (0.48) SLC34A2ENPP2SLC34A1SLC34A3SLC20A1
SCHEMBL267927 0.86 SLC34A2 (0.53) SLC34A2FAAHSLC34A1SLC34A3SLC20A1
SCHEMBL274314 0.86 SLC34A2 (0.53) SLC34A2FAAHSLC34A1SLC34A3SLC20A1
SCHEMBL267928 0.86 SLC34A2 (0.53) SLC34A2FAAHSLC34A1SLC34A3SLC20A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885ENPP2 178/4885FAAH 3575/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885ENPP2 191/4885FAAH 3435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.