Sugi Predict

Sugi Predict / Compounds / SCHEMBL268333

SCHEMBL268333

SCHEMBL268333

CCN(CC)Cc1cccc(C(=O)Nc2ccc(Cl)cc2C(=O)NOC(=O)c2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 1/20 0.52
▸ F10 P00742 3/20 0.52
▸ SERPINE1 P05121 3/20 0.48
▸ AKR1C4 P17516 1/20 0.47
▸ AKR1C3 P42330 1/20 0.47
▸ AKR1C2 P52895 1/20 0.47
▸ AKR1C1 Q04828 1/20 0.47
▸ MAPT P10636 2/20 0.46
▸ NPC1 O15118 2/20 0.46
▸ HPGD P15428 2/20 0.46
▸ RAB9A P51151 2/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ ALDH1A1 P00352 3/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ CA9 Q16790 1/20 0.44
▸ CYP1A2 P05177 1/20 0.44
▸ CYP3A4 P08684 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL274496 0.89 NPC1 (0.54) ACHEF10SERPINE1AKR1C4AKR1C3
SCHEMBL269119 0.86 F10 (0.55) ACHEF10SERPINE1AKR1C4AKR1C3
SCHEMBL268502 0.86 AKR1C4 (0.65) ACHEF10SERPINE1AKR1C4AKR1C3
SCHEMBL266028 0.73 SLC34A2 (0.54) ACHEF10AKR1C4AKR1C3AKR1C2
SCHEMBL266029 0.73 SLC34A2 (0.54) ACHEF10AKR1C4AKR1C3AKR1C2
SCHEMBL267931 0.73 HPGD (0.57) SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL265628 0.72 SLC34A2 (0.51) ACHEF10AKR1C4AKR1C3AKR1C2
SCHEMBL265627 0.72 SLC34A2 (0.51) ACHEF10AKR1C4AKR1C3AKR1C2
SCHEMBL265936 0.72 MAPT (0.49) F10MAPTNPC1HPGDRAB9A
SCHEMBL265935 0.72 MAPT (0.49) F10MAPTNPC1HPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 — — US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 — — US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 — — US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 ACHE 4048/4885F10 188/4885SERPINE1 1689/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 ACHE 3423/4885F10 338/4885SERPINE1 2189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.