Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | CPS1 | P31327 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26814607 | 0.85 | HTT (0.50) | HTTLMNAALOX15TSHRHSD17B10 | |
| SCHEMBL6279963 | 0.83 | PIK3CD (0.57) | HTTALDH1A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL26828135 | 0.81 | HTT (0.60) | HTTLMNAALOX15TSHRHSD17B10 | |
| SCHEMBL22054767 | 0.78 | KMT2A (0.59) | HTTTSHRALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL26835550 | 0.77 | L3MBTL1 (0.59) | HTTLMNAALOX15TSHRHSD17B10 | |
| SCHEMBL26827907 | 0.77 | HSD17B10 (0.85) | HTTLMNAALOX15TSHRHSD17B10 | |
| SCHEMBL3455900 | 0.77 | KMT2A (0.65) | HTTLMNATSHRALDH1A1HPGD | |
| SCHEMBL26827904 | 0.75 | MAPT (0.50) | TSHRL3MBTL1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL10722320 | 0.75 | HTT (0.89) | HTTTSHRHSD17B10ALDH1A1CYP2C9 | |
| SCHEMBL26835548 | 0.75 | CPS1 (0.54) | HTTLMNAALOX15TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | PDE4A, PDE4B, PDE5A | HTT 4024/4885LMNA 4118/4885ALOX15 1872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.