Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPS1 | P31327 | 5/20 | 0.54 |
| ▸ | GHSR | Q92847 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26827901 | 0.86 | CPS1 (0.51) | CPS1GHSRHTTL3MBTL1PARP1 | |
| SCHEMBL26814655 | 0.86 | CPS1 (0.51) | CPS1GHSRHTTL3MBTL1PARP1 | |
| SCHEMBL26817869 | 0.76 | CPS1 (0.50) | CPS1GHSRHTTL3MBTL1PARP1 | |
| SCHEMBL26835295 | 0.75 | HTT (0.54) | CPS1GHSRHTTL3MBTL1ALDH1A1 | |
| SCHEMBL3713071 | 0.74 | CPS1 (0.56) | CPS1GHSRHTTL3MBTL1ALDH1A1 | |
| SCHEMBL26828135 | 0.72 | HTT (0.60) | GHSRHTTL3MBTL1LMNAALOX15 | |
| SCHEMBL31416218 | 0.72 | HRH4 (0.48) | CPS1GHSRHTTL3MBTL1MEN1 | |
| SCHEMBL31416357 | 0.72 | HRH4 (0.48) | CPS1GHSRHTTL3MBTL1MEN1 | |
| SCHEMBL26835550 | 0.71 | L3MBTL1 (0.59) | GHSRHTTL3MBTL1ALDH1A1LMNA | |
| SCHEMBL22720326 | 0.71 | CPS1 (0.53) | CPS1GHSRHTTL3MBTL1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | PDE4A, PDE4B, PDE5A | CPS1 3443/4885GHSR 2357/4885HTT 4024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.