⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29820410 | 0.93 | CFD (0.35) | — | |
| SCHEMBL26816158 | 0.93 | CFD (0.35) | — | |
| SCHEMBL24665651 | 0.90 | CNR1 (0.32) | — | |
| SCHEMBL24666023 | 0.87 | DRD2 (0.33) | — | |
| SCHEMBL24665942 | 0.85 | — | — | |
| SCHEMBL24665990 | 0.84 | CFD (0.35) | — | |
| SCHEMBL30341388 | 0.84 | CFD (0.35) | — | |
| SCHEMBL29231043 | 0.84 | CFD (0.35) | — | |
| SCHEMBL29230648 | 0.84 | CFD (0.35) | — | |
| SCHEMBL26816108 | 0.84 | CFD (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814367-B2 | Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof | MAZE THERAPEUTICS, INC. (US) | 2023-11-14 | — | — | US | disclosed |