Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26837678 | 0.76 | EGFR (0.42) | EGFRJAK3JAK2CDK7CCNH | |
| SCHEMBL21808407 | 0.74 | CDK2 (0.42) | MAPTPOLBGPR142EGFRRAB9A | |
| SCHEMBL21808408 | 0.74 | CDK2 (0.42) | MAPTPOLBGPR142EGFRRAB9A | |
| SCHEMBL25646028 | 0.74 | IDO1 (0.48) | POLBSMN1; SMN2BCL2 | |
| SCHEMBL26835187 | 0.72 | TEK (0.55) | EGFRCDK7CCNHMNAT1BCL2 | |
| SCHEMBL30935156 | 0.72 | TGM2 (0.53) | EGFRJAK3JAK2JAK1 | |
| SCHEMBL18808346 | 0.72 | EGFR (0.63) | MAPTEGFRRAB9AJAK3JAK1 | |
| SCHEMBL22895557 | 0.67 | CCNK (0.47) | EGFRSMN1; SMN2GSTO1 | |
| SCHEMBL13181426 | 0.67 | TGM2 (0.53) | MAPTPOLBEGFR | |
| SCHEMBL15656086 | 0.67 | MAPT (0.64) | MAPTPOLBGPR142RAB9AXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3853225-B1 | N-(5-(3-(1-((THIAZOL-2-YL)AMINO)-1-OXOPROPAN-2-YL)PHENYL)PYRIDIN-2-YL)ACRYLAMIDE DERIVATIVES AS CDK7 INHIBITORS FOR THE TREATMENT OF CANCER | YUNGJIN PHARMACEUTICAL CO LTD (KR) | 2023-11-29 | — | — | EP | disclosed |