Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 8/20 | 0.53 |
| ▸ | JAK1 | P23458 | 5/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | BTK | Q06187 | 4/20 | 0.50 |
| ▸ | ITK | Q08881 | 2/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935219 | 0.75 | PARP10 (0.52) | JAK3JAK1JAK2BTKITK | |
| SCHEMBL23721295 | 0.74 | MAP2K7 (0.60) | TGM2JAK3JAK1JAK2BTK | |
| SCHEMBL26837665 | 0.72 | MAPT (0.43) | JAK3JAK1JAK2EGFR | |
| SCHEMBL4103284 | 0.72 | TGM2 (0.76) | TGM2JAK3BTKITKMAP2K7 | |
| SCHEMBL30190722 | 0.71 | JAK3 (0.51) | TGM2JAK3JAK1JAK2BTK | |
| SCHEMBL24150517 | 0.71 | JAK3 (0.51) | TGM2JAK3JAK1JAK2BTK | |
| SCHEMBL24150191 | 0.71 | JAK3 (0.51) | JAK3JAK1JAK2BTKITK | |
| SCHEMBL30190875 | 0.71 | JAK3 (0.51) | JAK3JAK1JAK2BTKITK | |
| SCHEMBL25053131 | 0.71 | JAK3 (0.56) | JAK3JAK1JAK2BTKITK | |
| SCHEMBL12807117 | 0.71 | JAK3 (0.59) | TGM2JAK3JAK1JAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024125464-A1 | TETRAHYDROISOQUINOLIN-ONE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-06-20 | — | — | WO | disclosed |