SCHEMBL268399

SCHEMBL268399

CCN(CC)CCN(C)Cc1cccc(C(=O)Nc2ccc(OC)cc2C(=O)NN=Cc2ccc(Cl)c(C(F)(F)F)c2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 11/20 0.56
MAPT P10636 4/20 0.43
RAB9A P51151 2/20 0.43
LMNA P02545 1/20 0.43
GAA P10253 1/20 0.43
KDM4E B2RXH2 3/20 0.42
POLB P06746 1/20 0.42
HPGD P15428 3/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C19 P33261 1/20 0.42
ATM Q13315 1/20 0.42
NPC1 O15118 1/20 0.41
ALDH1A1 P00352 1/20 0.41
MEN1 O00255 1/20 0.40
PKM P14618 1/20 0.40
ALOX12 P18054 1/20 0.40
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
SLC34A1 Q06495 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL274169 1.00 SLC34A2 (0.56) SLC34A2MAPTRAB9ALMNAGAA
SCHEMBL268398 1.00 SLC34A2 (0.56) SLC34A2MAPTRAB9ALMNAGAA
SCHEMBL274480 0.94 SLC34A2 (0.54) SLC34A2MAPTRAB9AKDM4EHPGD
SCHEMBL269314 0.94 SLC34A2 (0.54) SLC34A2MAPTRAB9AKDM4EHPGD
SCHEMBL269315 0.94 SLC34A2 (0.54) SLC34A2MAPTRAB9AKDM4EHPGD
SCHEMBL267744 0.92 SLC34A2 (0.54) SLC34A2MAPTRAB9AKDM4EHPGD
SCHEMBL267745 0.92 SLC34A2 (0.54) SLC34A2MAPTRAB9AKDM4EHPGD
SCHEMBL274267 0.92 SLC34A2 (0.54) SLC34A2MAPTRAB9AKDM4EHPGD
SCHEMBL267983 0.92 SLC34A2 (0.60) SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1
SCHEMBL267984 0.92 SLC34A2 (0.60) SLC34A2SLC34A1SLC34A3SLC20A1ADCYAP1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885MAPT 4195/4885RAB9A 883/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885MAPT 4648/4885RAB9A 1362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.