Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | GLS | O94925 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30672455 | 0.86 | LMNA (0.42) | LMNAKMT2ASYKCYP17A1ATR | |
| SCHEMBL26839481 | 0.82 | KMT2A (0.44) | LMNAKMT2ACYP17A1ATRPTGER1 | |
| SCHEMBL30672422 | 0.82 | KMT2A (0.44) | LMNAKMT2ACYP17A1ATRPTGER1 | |
| SCHEMBL26663508 | 0.82 | HCAR3 (0.38) | KMT2AGLSSCN9ACA1CA2 | |
| SCHEMBL30672385 | 0.79 | KMT2A (0.47) | LMNAKMT2ACYP17A1ATRPTGER1 | |
| SCHEMBL26839582 | 0.79 | KMT2A (0.47) | LMNAKMT2ACYP17A1ATRPTGER1 | |
| SCHEMBL30672253 | 0.78 | KMT2A (0.39) | LMNAKMT2ACYP17A1ATRPTGER1 | |
| SCHEMBL25317169 | 0.75 | ATR (0.39) | KMT2ACYP17A1ATRGLSSCN9A | |
| SCHEMBL31656043 | 0.75 | CYP17A1 (0.39) | KMT2ACYP17A1ATRGLSSCN9A | |
| SCHEMBL29442854 | 0.73 | LMNA (0.53) | LMNAKMT2ACYP17A1ATRPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225664-A1 | LACTAM SUBSTITUTED IMIDAZOPYRIDAZINE IL-17A MODULATORS AND USES THEREOF | DICE ALPHA, INC. (US) | 2023-11-23 | — | — | WO | disclosed |