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SCHEMBL26845152

SCHEMBL26845152

O=C(NSc1ccccc1)c1ccc(N2CCN(Cc3ccccc3-c3cncc(O)c3)CC2)cc1

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ BCL2 P10415 15/20 0.48
▸ BAK1 Q16611 4/20 0.48
▸ HTR7 P34969 2/20 0.45
▸ BCL2L1 Q07817 13/20 0.45
▸ KDM4E B2RXH2 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43
▸ BAD Q92934 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24619853 0.88 BCL2 (0.47) BCL2BAK1HTR7BCL2L1KDM4E
SCHEMBL26683082 0.86 HTR7 (0.53) BCL2BAK1HTR7BCL2L1KDM4E
SCHEMBL26681641 0.83 BCL2 (0.56) BCL2BAK1BCL2L1BAD
SCHEMBL29792980 0.83 BCL2 (0.56) BCL2BAK1BCL2L1BAD
SCHEMBL26680907 0.83 BCL2 (0.70) BCL2BAK1BCL2L1
SCHEMBL26681292 0.83 BCL2 (0.52) BCL2BAK1BCL2L1
SCHEMBL26845174 0.83 BCL2 (0.47) BCL2BAK1HTR7BCL2L1KDM4E
SCHEMBL29793220 0.82 BCL2 (0.58) BCL2BAK1BCL2L1
SCHEMBL26680650 0.82 BCL2 (0.58) BCL2BAK1BCL2L1
SCHEMBL24620096 0.81 BCL2 (0.46) BCL2BAK1HTR7BCL2L1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4279476-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-22 — — EP disclosed