SCHEMBL268492

SCHEMBL268492

O=C(O)C1Cc2ccccc2C(O)N1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.53
GAA P10253 1/20 0.53
KDM4E B2RXH2 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TSHR P16473 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
GRIN2D O15399 1/20 0.41
GRIN3B O60391 1/20 0.41
GRIN1 Q05586 1/20 0.41
GRIN2A Q12879 1/20 0.41
GRIN2B Q13224 1/20 0.41
GRIN2C Q14957 1/20 0.41
GRIN3A Q8TCU5 1/20 0.41
ALDH1A1 P00352 2/20 0.39
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
HPGD P15428 1/20 0.39
CYP2D6 P10635 1/20 0.38
MAPK1 P28482 1/20 0.38
MME P08473 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29430156 1.00 MAPT (0.53) MAPTGAAKDM4ESMN1; SMN2TSHR
SCHEMBL31650932 0.83 MAPT (0.53) MAPTGAAKDM4ESMN1; SMN2TSHR
SCHEMBL27398624 0.83 MAPT (0.53) MAPTGAAKDM4ESMN1; SMN2TSHR
SCHEMBL28787105 0.83 MAPT (0.53) MAPTGAAKDM4ESMN1; SMN2TSHR
SCHEMBL12500797 0.81 MAPT (0.51) MAPTGAAKDM4ESMN1; SMN2TSHR
Hydrochloric Acid SCHEMBL28852828 0.81 MAPT (0.51) MAPTGAAKDM4ESMN1; SMN2TSHR
SCHEMBL27931562 0.81 MAPT (0.51) MAPTGAAKDM4ESMN1; SMN2TSHR
SCHEMBL28243696 0.81 MAPT (0.51) MAPTGAAKDM4ESMN1; SMN2TSHR
SCHEMBL8722537 0.81 MAPT (0.51) MAPTGAAKDM4ESMN1; SMN2TSHR
SCHEMBL28197623 0.81 MAPT (0.51) MAPTGAAKDM4ESMN1; SMN2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 758 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6338945-B1 CONCURRENT SCREENING OF OLIGOPEPTIDE LIBRARIES SYNTHESIZED ON SOLID PHASE SUPPORTS TO ISOLATE BIOACTIVE MOLECULES WHICH ELICIT CYTOLYTIC ACTIVITY GENZYME CORPORATION 2002-01-15 US claimed
US-12528849-B2 WT1 HLA class II-binding peptides and compositions and methods comprising same MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2026-01-20 US disclosed
US-20250186563-A1 UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME ALEXION PHARMA INC (US) 2025-06-12 US disclosed
EP-3604510-B1 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME ALEXION PHARMA INC (US) 2025-03-26 EP disclosed
US-20250092380-A1 ANTIDOTES TO FACTOR XA INHIBITORS ALEXION PHARMA INC (US) 2025-03-20 US disclosed
US-12195774-B2 Antidotes to factor XA inhibitors ALEXION PHARMACEUTICALS, INC. (US) 2025-01-14 US disclosed
US-20240408197-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-12-12 US disclosed
US-20240368220-A1 IMMUNOGENIC WT-1 PEPTIDES AND METHODS OF USE THEREOF MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-11-07 US disclosed
US-20240287174-A1 HIDE1 COMPOSITIONS AND METHODS COMPUGEN LTD (IL) 2024-08-29 US disclosed
US-20240189401-A1 UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME ALEXION PHARMA INC (US) 2024-06-13 US disclosed
WO-1997035035-A1 A METHOD FOR IDENTIFYING CYTOTOXIC T-CELL EPITOPES NICOLETTE CHARLES (US) 1997-09-25 WO disclosed
US-5650489-A SOLID PHASE SYNTHESIS OF PEPTIDES, RANDOM SEQUENCES, COMBINATORIAL CHEMISTRY THE ARIZONA BOARD OF REGENTS (US) 1997-07-22 US disclosed
US-5510240-A Method of screening a peptide library THE ARIZONA BOARD OF REGENTS (US) 1996-04-23 US disclosed
EP-0705279-A1 TOPOLOGICALLY SEGREGATED, ENCODED SOLID PHASE LIBRARIES SELECTIDE CORPORATION (US) 1996-04-10 EP disclosed
US-5470753-A Peptide sequencing using mass spectrometry SELECTIDE CORPORATION (US) 1995-11-28 US disclosed
WO-1994028028-A1 TOPOLOGICALLY SEGREGATED, ENCODED SOLID PHASE LIBRARIES SELECTIDE CORPORATION (US) 1994-12-08 WO disclosed
WO-1994006017-A1 PEPTIDE SEQUENCING USING MASS SPECTROMETRY SELECTIDE CORPORATION (US) 1994-03-17 WO disclosed
EP-0542770-A4 RANDOM BIO-OLIGOMER LIBRARY, A METHOD OF SYNTHESIS THEREOF, AND A METHOD OF USE THEREOF 1993-09-15 EP disclosed
EP-0542770-A1 RANDOM BIO-OLIGOMER LIBRARY, A METHOD OF SYNTHESIS THEREOF, AND A METHOD OF USE THEREOF ARIZONA BOARD OF REGENTS a body corporate acting on behalf of Arizona State University (US) 1993-05-26 EP disclosed
WO-1992000091-A1 RANDOM BIO-OLIGOMER LIBRARY, A METHOD OF SYNTHESIS THEREOF, AND A METHOD OF USE THEREOF BIOLIGAND, INC. (US) 1992-01-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240189401-A1 UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME SERPINC1, F8, F9 MAPT 4594/4885GAA 612/4885KDM4E 3562/4885
US-20250092380-A1 ANTIDOTES TO FACTOR XA INHIBITORS SERPINC1, F2, F8 MAPT 4748/4885GAA 1000/4885KDM4E 2505/4885
US-20250186563-A1 UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME SERPINC1, F8, F9 MAPT 4594/4885GAA 612/4885KDM4E 3562/4885
US-12195774-B2 Antidotes to factor XA inhibitors SERPINC1, F2, F8 MAPT 4748/4885GAA 1000/4885KDM4E 2505/4885
US-12528849-B2 WT1 HLA class II-binding peptides and compositions and methods comprising same MICA, HLA-DRB1, TAP2 MAPT 3433/4885GAA 4725/4885KDM4E 1583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.