Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | MAP2K3 | P46734 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21199669 | 0.81 | POLB (0.43) | CFTRMAP2K3POLBKDM4ELMNA | |
| SCHEMBL18109486 | 0.81 | NPSR1 (0.44) | CFTRKDM4EPKM | |
| SCHEMBL30608970 | 0.81 | NPSR1 (0.44) | CFTRKDM4EPKM | |
| SCHEMBL16505391 | 0.78 | CFTR (0.42) | CFTRMAP2K3DGAT1IKBKBIDO1 | |
| SCHEMBL21219060 | 0.76 | MAP4K1 (0.40) | CFTRMAP2K3POLBKDM4ELMNA | |
| SCHEMBL30951245 | 0.74 | SMN1; SMN2 (0.39) | CFTRKDM4EPKMIKBKBMEN1 | |
| SCHEMBL27194684 | 0.73 | TERT (0.33) | KDM4ELMNA | |
| SCHEMBL23620176 | 0.71 | TERT (0.37) | MEN1KMT2A | |
| SCHEMBL29829945 | 0.71 | TERT (0.37) | MEN1KMT2A | |
| SCHEMBL16505587 | 0.71 | IDO1 (0.45) | CFTRMAP2K3DGAT1SOAT1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217906-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |