SCHEMBL268517

SCHEMBL268517

Cc1ccc(C=NNC(=O)c2c(C)csc2NC(=O)c2cccc(CN3CCC(CO)CC3)c2)cc1C

nearest known ligand 0.51

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 4/20 0.50
ACKR3 P25106 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.38
CCR3 P51677 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL268516 1.00 SLC34A2 (0.50) SLC34A2ACKR3L3MBTL1CCR3
SCHEMBL268603 0.93 SLC34A2 (0.49) SLC34A2
SCHEMBL268604 0.93 SLC34A2 (0.49) SLC34A2
SCHEMBL270414 0.92 SLC34A2 (0.58) SLC34A2ACKR3L3MBTL1
SCHEMBL270415 0.92 SLC34A2 (0.58) SLC34A2ACKR3L3MBTL1
SCHEMBL266897 0.92 SLC34A2 (0.49) SLC34A2L3MBTL1
SCHEMBL266898 0.92 SLC34A2 (0.49) SLC34A2L3MBTL1
SCHEMBL265863 0.91 SLC34A2 (0.49) SLC34A2ACKR3
SCHEMBL265864 0.91 SLC34A2 (0.49) SLC34A2ACKR3
SCHEMBL269356 0.91 SLC34A2 (0.47) SLC34A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885ACKR3 751/4885L3MBTL1 934/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885ACKR3 809/4885L3MBTL1 1096/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.