Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26863362 | 0.91 | BRAF (0.36) | BRAFALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL26656465 | 0.91 | BRAF (0.36) | BRAFALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL30666116 | 0.91 | BRAF (0.36) | BRAFALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL26863370 | 0.87 | BRAF (0.38) | BRAFALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL26871089 | 0.87 | BRAF (0.38) | BRAFALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL24028628 | 0.78 | KDR (0.45) | — | |
| SCHEMBL25465681 | 0.78 | KDR (0.45) | — | |
| SCHEMBL25467266 | 0.78 | KDR (0.45) | — | |
| SCHEMBL25467199 | 0.78 | KDR (0.45) | — | |
| SCHEMBL30666124 | 0.74 | FGFR2 (0.33) | BRAFALDH1A1SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225001-A1 | NAPHTHYRIDINE BASED ENPP1 MODULATORS AND USES THEREOF | Vir Biotechnology, Inc. (US) | 2023-11-23 | — | — | WO | disclosed |