Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.33 |
| ▸ | KDR | P35968 | 6/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26656465 | 1.00 | BRAF (0.36) | BRAFGAALMNATSHRHTT | |
| SCHEMBL26863362 | 1.00 | BRAF (0.36) | BRAFGAALMNATSHRHTT | |
| SCHEMBL26863368 | 0.91 | BRAF (0.36) | BRAFGAALMNATSHRHTT | |
| SCHEMBL26863370 | 0.88 | BRAF (0.38) | BRAFGAALMNATSHRHTT | |
| SCHEMBL26871089 | 0.88 | BRAF (0.38) | BRAFGAALMNATSHRHTT | |
| SCHEMBL26864188 | 0.82 | BRAF (0.36) | BRAFGAAHTTPDGFRAKDR | |
| SCHEMBL26656440 | 0.82 | BRAF (0.36) | BRAFGAAHTTPDGFRAKDR | |
| SCHEMBL26865331 | 0.82 | BRAF (0.36) | BRAFGAAHTTPDGFRAKDR | |
| SCHEMBL30666120 | 0.82 | BRAF (0.36) | BRAFGAAHTTPDGFRAKDR | |
| SCHEMBL24028628 | 0.82 | KDR (0.45) | PDGFRAKDRFGFR2METCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225001-A1 | NAPHTHYRIDINE BASED ENPP1 MODULATORS AND USES THEREOF | Vir Biotechnology, Inc. (US) | 2023-11-23 | — | — | WO | disclosed |