⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29073920 | 1.00 | — | — | |
| SCHEMBL26092432 | 0.82 | CFD (0.32) | — | |
| SCHEMBL30296580 | 0.82 | CFD (0.32) | — | |
| SCHEMBL24571288 | 0.82 | CFD (0.32) | — | |
| SCHEMBL26880625 | 0.82 | CFD (0.32) | — | |
| SCHEMBL30296382 | 0.81 | PDCD1LG2 (0.30) | — | |
| SCHEMBL30296381 | 0.76 | — | — | |
| SCHEMBL29073831 | 0.74 | — | — | |
| SCHEMBL29073828 | 0.74 | — | — | |
| SCHEMBL30390616 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161642-B1 | N-PHENYLAMINOCARBONYL PYRIDINO- , PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65 | PATHIOS THERAPEUTICS LTD (GB) | 2026-05-27 | — | — | EP | disclosed |
| US-20230373989-A1 | N-PHENYLAMINOCARBONYL PYRIDINO-, PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65 | Pathios Therapeutics Limited (GB) | 2023-11-23 | — | — | US | disclosed |
| US-20230373989-A1 | N-PHENYLAMINOCARBONYL PYRIDINO-, PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65 | Pathios Therapeutics Limited (GB) | 2023-11-23 | — | — | US | disclosed |
| US-20230373989-A1 | N-PHENYLAMINOCARBONYL PYRIDINO-, PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65 | Pathios Therapeutics Limited (GB) | 2023-11-23 | — | — | US | disclosed |
| CN-116783195-A | N-phenylaminocarbonyl pyridinyl-, pyrimidinyl and benzo-tropanes as modulators of GPR65 | 帕蒂奥斯治疗有限公司 | 2023-09-19 | — | — | CN | disclosed |
| EP-4161642-A1 | N-PHENYLAMINOCARBONYL PYRIDINO-, PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65 | Pathios Therapeutics Limited (GB) | 2023-04-12 | — | — | EP | disclosed |