⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24571288 | 0.79 | CFD (0.32) | — | |
| SCHEMBL30296580 | 0.79 | CFD (0.32) | — | |
| SCHEMBL26880625 | 0.79 | CFD (0.32) | — | |
| SCHEMBL26092432 | 0.79 | CFD (0.32) | — | |
| SCHEMBL30296382 | 0.78 | PDCD1LG2 (0.30) | — | |
| SCHEMBL29073920 | 0.76 | — | — | |
| SCHEMBL26880652 | 0.76 | — | — | |
| SCHEMBL30296007 | 0.74 | GAA (0.37) | — | |
| SCHEMBL30296413 | 0.74 | — | — | |
| SCHEMBL31026776 | 0.72 | HTT (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368173-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-11-07 | — | — | US | disclosed |
| EP-4419203-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023067322-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2023-04-27 | — | — | WO | disclosed |