Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 4/20 | 0.66 |
| ▸ | KRAS | P01116 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | METAP2 | P50579 | 2/20 | 0.51 |
| ▸ | METAP1 | P53582 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18702600 | 0.80 | SPR (1.00) | SPRKRASRAB9ANPC1LMNA | |
| SCHEMBL2408228 | 0.79 | SMN1; SMN2 (0.60) | SPRKRASRAB9AALDH1A1HTT | |
| SCHEMBL26158246 | 0.78 | SPR (0.67) | SPRKRASRAB9AL3MBTL1MAPT | |
| SCHEMBL26676961 | 0.77 | KRAS (1.00) | SPRKRASRAB9ANPC1LMNA | |
| SCHEMBL18997467 | 0.77 | KRAS (0.56) | KRASRAB9ANPC1LMNAALDH1A1 | |
| SCHEMBL14343746 | 0.77 | NPC1 (0.57) | SPRKRASRAB9ANPC1LMNA | |
| SCHEMBL18702370 | 0.77 | SPR (1.00) | SPRKRASRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL29764050 | 0.76 | NPC1 (1.00) | KRASRAB9ANPC1LMNAALDH1A1 | |
| SCHEMBL10709261 | 0.76 | NPC1 (1.00) | KRASRAB9ANPC1LMNAALDH1A1 | |
| SCHEMBL30169443 | 0.76 | NPC1 (1.00) | KRASRAB9ANPC1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4416156-A1 | COMPOUNDS AND METHODS FOR MODULATING NUCLEIC ACID SPLICING | Remix Therapeutics Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| EP-3642209-B1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY Therapeutics LLC (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2023064879-A1 | COMPOUNDS AND METHODS FOR MODULATING NUCLEIC ACID SPLICING | REMIX THERAPEUTICS INC. (US) | 2023-04-20 | — | — | WO | disclosed |