Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 10/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | RICTOR | Q6R327 | 8/20 | 0.32 |
| ▸ | MAPKAP1 | Q9BPZ7 | 8/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 2/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2690501 | 0.88 | BCHE (0.34) | BCHEACHEBRD4PLK1 | |
| SCHEMBL2688281 | 0.78 | GAA (0.34) | MTORRICTORMAPKAP1MLST8CYP2C8 | |
| SCHEMBL2688782 | 0.76 | TRPM8 (0.35) | MTORPIK3CARICTORMAPKAP1MLST8 | |
| SCHEMBL2691232 | 0.74 | BCHE (0.34) | BCHEACHE | |
| SCHEMBL1288653 | 0.74 | GRM5 (0.34) | — | |
| SCHEMBL1688396 | 0.72 | GRM5 (0.32) | — | |
| SCHEMBL2343135 | 0.71 | BCHE (0.36) | BCHEACHEALDH1A1MAPTKMT2A | |
| SCHEMBL2343142 | 0.71 | BCHE (0.36) | BCHEACHEALDH1A1MAPTKMT2A | |
| SCHEMBL2345268 | 0.71 | BCHE (0.35) | BCHEACHEALDH1A1MAPTKMT2A | |
| SCHEMBL2690643 | 0.70 | PLK1 (0.44) | MTORRICTORMAPKAP1MLST8CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115848-A1 | Inhibitors of Polo-Like Kinase | ELAN PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120115848-A1 | Inhibitors of Polo-Like Kinase | ELAN PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115848-A1 | Inhibitors of Polo-Like Kinase | PLK1, POLR2E, POLR2H | BCHE 3133/4885ACHE 2386/4885MTOR 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.