Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.97 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | PKM | P14618 | 1/20 | 0.97 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | THPO | P40225 | 1/20 | 0.97 |
| ▸ | BLM | P54132 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fusaric Acid SCHEMBL178006 | 0.98 | ALDH1A1 (1.00) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 | |
| Fusaric Acid SCHEMBL8606376 | 0.98 | ALDH1A1 (1.00) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 | |
| Fusaric Acid SCHEMBL29406685 | 0.98 | ALDH1A1 (1.00) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 | |
| Fusaric Acid SCHEMBL27759120 | 0.97 | ALDH1A1 (0.97) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 | |
| Fusaric Acid SCHEMBL8557482 | 0.97 | ALDH1A1 (0.97) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 | |
| Fusaric Acid SCHEMBL2270496 | 0.97 | ALDH1A1 (0.97) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 | |
| Fusaric Acid SCHEMBL11662860 | 0.97 | ALDH1A1 (0.97) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 | |
| Fusaric Acid SCHEMBL10339040 | 0.97 | ALDH1A1 (0.97) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 | |
| Fusaric Acid SCHEMBL11662856 | 0.95 | NFKB1 (0.94) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 | |
| SCHEMBL2689054 | 0.95 | ALDH1A1 (0.88) | ALDH1A1NFKB1KDM4EL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101001-B1 | DEUTERATED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | TEVA PHARMACEUTICALS INT GMBH (CH) | 2020-04-01 | — | — | EP | claimed |
| US-RE46629-E1 | Deuterated catecholamine derivatives and medicaments compromising said compounds | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2017-12-12 | — | — | US | claimed |
| US-RE46555-E1 | Deuterated catecholamine derivatives and medicaments comprising said compounds | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2017-09-19 | — | — | US | claimed |
| EP-3101001-A1 | DEUTERATED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | ratiopharm GmbH (DE) | 2016-12-07 | — | — | EP | claimed |
| EP-1991522-B1 | DEUTERATED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | IMPHAR AG (DE) | 2016-05-18 | — | — | EP | claimed |
| US-20150376117-A1 | POSITION-SPECIFIC ASYMMETRIC DEUTERIUM ENRICHED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2015-12-31 | — | — | US | claimed |
| EP-2953926-A1 | POSITION-SPECIFIC ASYMMETRIC DEUTERIUM ENRICHED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | imphar Aktiengesellschaft (DE) | 2015-12-16 | — | — | EP | claimed |
| WO-2014122184-A1 | POSITION-SPECIFIC ASYMMETRIC DEUTERIUM ENRICHED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | CDRD BEROLINA AB (SE) | 2014-08-14 | — | — | WO | claimed |
| US-8247603-B2 | Deuterated catecholamine derivatives and medicaments comprising said compounds | BIRDS PHARMA GMBH BEROLINA INNOVATIVE (DE) | 2012-08-21 | — | — | US | claimed |
| US-8168820-B2 | Deuterated catecholamine derivatives and medicaments comprising said compounds | BDD BEROLINA DRUG DEVELOPMENT GMBH (DE) | 2012-05-01 | — | — | US | claimed |
| CN-100584807-C | Deuterated catecholamine derivatives and medicaments containing said compounds | BDD BEROLINA DRUG DEV GMBH | 2010-01-27 | — | — | CN | claimed |
| EP-1613571-B1 | DEUTERATED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BDD BEROLINA DRUG DEV GMBH (DE) | 2009-12-09 | — | — | EP | claimed |
| CN-101384545-A | Deuterated catecholamine derivatives and medicaments comprising said compounds | BIRDS PHARMA GMBH BEROLINA INN (DE) | 2009-03-11 | — | — | CN | claimed |
| US-20090018191-A1 | Deuterated Catecholamine Derivatives and Medicaments Comprising Said Compounds | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2009-01-15 | — | — | US | claimed |
| EP-1991522-A2 | DEUTERATED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | Birds Pharma GmbH Berolina Innovative Research & Development Services (DE) | 2008-11-19 | — | — | EP | claimed |
| WO-2007093450-A2 | DEUTERATED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BIRDS PHARMA GMBH BEROLINA INNOVATIVE RESEARCH & DEVELOPMENT SERVICES (DE) | 2007-08-23 | — | — | WO | claimed |
| US-20070082953-A1 | Use of l-dopa, derivatives thereof and medicaments comprising said compounds for the prophylaxis of psychotic diseases | BDD BEROLINA DRUG DEVELOPMENT GMBH (DE) | 2007-04-12 | — | — | US | claimed |
| US-20060135615-A1 | Deuterated catecholamine derivatives and medicaments comprising said compounds | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2006-06-22 | — | — | US | claimed |
| CN-1756542-A | Use of L-dopa, derivatives thereof and medicaments containing said compounds for the prevention of psychotic disorders | BDD GROUP HOLDING AG (DE) | 2006-04-05 | — | — | CN | claimed |
| CN-1738782-A | Deuterated catecholamine derivatives and medicaments containing said compounds | BDD BEROLINA DRUG DEV GMBH (DE) | 2006-02-22 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018191-A1 | Deuterated Catecholamine Derivatives and Medicaments Comprising Said Compounds | COMT, DDT, TYR | ALDH1A1 775/4885NFKB1 4226/4885KDM4E 1504/4885 |
| US-20060135615-A1 | Deuterated catecholamine derivatives and medicaments comprising said compounds | COMT, DDT, TYR | ALDH1A1 821/4885NFKB1 4324/4885KDM4E 1596/4885 |
| US-20150376117-A1 | POSITION-SPECIFIC ASYMMETRIC DEUTERIUM ENRICHED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS | COMT, DBH, DDT | ALDH1A1 2135/4885NFKB1 3701/4885KDM4E 2760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.