SCHEMBL268988

SCHEMBL268988

Cc1csc(NC(=O)c2cccc(CN(CCO)CCO)c2)c1C(=O)NN=Cc1ccc(Cl)c(C(F)(F)F)c1

nearest known ligand 0.55

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 12/20 0.55
ADCYAP1R1 P41586 5/20 0.36
SLC34A1 Q06495 1/20 0.35
SLC34A3 Q8N130 1/20 0.35
SLC20A1 Q8WUM9 1/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL268987 1.00 SLC34A2 (0.55) SLC34A2ADCYAP1R1SLC34A1SLC34A3SLC20A1
SCHEMBL274341 1.00 SLC34A2 (0.55) SLC34A2ADCYAP1R1SLC34A1SLC34A3SLC20A1
SCHEMBL266258 0.94 SLC34A2 (0.60) SLC34A2ADCYAP1R1
SCHEMBL266259 0.94 SLC34A2 (0.60) SLC34A2ADCYAP1R1
SCHEMBL274446 0.94 SLC34A2 (0.60) SLC34A2ADCYAP1R1
SCHEMBL267339 0.91 SLC34A2 (0.55) SLC34A2ADCYAP1R1LMNAGAAMAPT
SCHEMBL267338 0.91 SLC34A2 (0.55) SLC34A2ADCYAP1R1LMNAGAAMAPT
SCHEMBL273945 0.91 SLC34A2 (0.55) SLC34A2ADCYAP1R1LMNAGAAMAPT
SCHEMBL266193 0.91 SLC34A2 (0.52) SLC34A2ADCYAP1R1SLC34A1SLC34A3SLC20A1
SCHEMBL273805 0.91 SLC34A2 (0.52) SLC34A2ADCYAP1R1SLC34A1SLC34A3SLC20A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885ADCYAP1R1 1941/4885SLC34A1 4/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885ADCYAP1R1 1219/4885SLC34A1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.