Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Suxamethonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.95 |
| ▸ | MAPT | P10636 | 1/20 | 0.91 |
| ▸ | BLM | P54132 | 1/20 | 0.91 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.62 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.62 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.62 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.62 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Suxamethonium SCHEMBL21356923 | 1.00 | ADRA2A (0.95) | ADRA2AADRA1AMAPTBLMCYP2C19 | |
| Suxamethonium SCHEMBL41537 | 0.97 | ADRA2A (1.00) | ADRA2AADRA1AMAPTBLMCYP2C19 | |
| Suxamethonium SCHEMBL2821312 | 0.95 | ADRA2A (0.95) | ADRA2AADRA1AMAPTBLMCYP2C19 | |
| Suxamethonium SCHEMBL16320883 | 0.95 | ADRA2A (0.95) | ADRA2AADRA1AMAPTBLMCYP2C19 | |
| Suxamethonium SCHEMBL41536 | 0.95 | MAPT (1.00) | ADRA2AADRA1AMAPTBLMCYP2C19 | |
| Suxamethonium SCHEMBL1643328 | 0.95 | ADRA2A (0.95) | ADRA2AADRA1AMAPTBLMCYP2C19 | |
| Suxamethonium SCHEMBL20815392 | 0.93 | MAPT (0.95) | ADRA2AADRA1AMAPTBLMCYP2C19 | |
| Suxamethonium SCHEMBL1983256 | 0.93 | MAPT (0.95) | ADRA2AADRA1AMAPTBLMCYP2C19 | |
| Hydrochloric Acid SCHEMBL27500997 | 0.89 | ADRA2A (0.76) | ADRA2AADRA1AMAPTBLMCYP2C19 | |
| Hydrochloric Acid SCHEMBL19025642 | 0.89 | ADRA2A (0.75) | ADRA2AADRA1AMAPTBLMCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3391884-B1 | TRANSDERMALLY ABSORBABLE PREPARATION | KM TRANSDERM LTD (JP) | 2024-04-10 | — | — | EP | disclosed |
| US-20240075267-A1 | Microneedle Array Device, Methods Of Manufacturing And Use Thereof | NanoCav, LLC | 2024-03-07 | — | — | US | disclosed |
| US-20240075266-A1 | Microneedle Array Device, Methods Of Manufacturing And Use Thereof | NanoCav, LLC | 2024-03-07 | — | — | US | disclosed |
| US-11786480-B2 | Transdermally absorbable preparation | KM Transderm Ltd. (JP) | 2023-10-17 | — | — | US | disclosed |
| WO-2023138680-A1 | METHOD FOR INDUCING CELL DIFFERENTIATION | 科济生物医药（上海）有限公司 | 2023-07-27 | — | — | WO | disclosed |
| EP-3391936-B1 | MICRONEEDLE SHEET | HISAMITSU PHARMACEUTICAL CO (JP) | 2022-11-30 | — | — | EP | disclosed |
| CN-114790446-A | Cervical adenocarcinoma organoid culture medium and construction method thereof | 中山大学附属第一医院 | 2022-07-26 | — | — | CN | disclosed |
| US-11130148-B2 | System for manufacturing microneedle preparation, and air-conditioning method | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2021-09-28 | — | — | US | disclosed |
| EP-3040068-B1 | ADHESIVE SHEET FOR APPLICATION TO THE SKIN, AND PERCUTANEOUS ABSORPTION PREPARATION USING SAME | KM TRANSDERM LTD (JP) | 2021-08-18 | — | — | EP | disclosed |
| EP-3254677-B1 | ADHESIVE PATCH | HISAMITSU PHARMACEUTICAL CO (JP) | 2021-08-04 | — | — | EP | disclosed |
| EP-1870413-A1 | ANTIPRURITIC AGENT FOR PRURITUS CAUSED BY MULTIPLE SCLEROSIS | TORAY INDUSTRIES, INC. (JP) | 2007-12-26 | — | — | EP | disclosed |
| US-20070196455-A1 | Crosslinkable pressure-sensitive adhesive for skin | SAITAMA DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-08-23 | — | — | US | disclosed |
| EP-1806152-A1 | DRUG FOR EXTERNAL USE AND ADHESIVE PATCH | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2007-07-11 | — | — | EP | disclosed |
| EP-1806151-A1 | DRUG FOR EXTERNAL USE AND ADHESIVE PATCH | Hisamitsu Pharmaceutical Co., Ltd. (JP) | 2007-07-11 | — | — | EP | disclosed |
| EP-1741448-A1 | CROSSLINKABLE PRESSURE-SENSITIVE ADHESIVE FOR THE SKIN | Saitama Daiichi Pharmaceutical Co., Ltd. (JP) | 2007-01-10 | — | — | EP | disclosed |
| EP-1702955-A1 | PRESSURE-SENSITIVE ADHESIVE COMPOSITION AND SKIN PATCH | HISAMITSU PHARMACEUTICAL CO. INC. (JP) | 2006-09-20 | — | — | EP | disclosed |
| US-20050260255-A1 | Adhesive patch | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2005-11-24 | — | — | US | disclosed |
| EP-1541177-A1 | ADHESIVE PATCH | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-20050042269-A1 | Plaster having laminated support | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2005-02-24 | — | — | US | disclosed |
| EP-1462121-A1 | PLASTER HAVING LAMINATED SUPPORT | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2004-09-29 | — | — | EP | disclosed |