Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | CTSK | P43235 | 2/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 16/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL268364 | 0.91 | CTSS (0.52) | CTSSCTSKSCN9ASCN10APTPN1 | |
| SCHEMBL268422 | 0.90 | CTSS (0.51) | CTSSCTSKSCN9ASCN10APTPN1 | |
| SCHEMBL267981 | 0.83 | CTSS (0.58) | CTSSCTSKSCN9ASCN10APTPN1 | |
| SCHEMBL267858 | 0.83 | CTSS (0.48) | CTSSCTSKSCN9ASCN10APTPN1 | |
| SCHEMBL269249 | 0.81 | SCN9A (0.48) | CTSSCTSKSCN9ASCN10APTPN1 | |
| SCHEMBL277718 | 0.80 | SCN9A (0.41) | CTSSCTSKSCN9ASCN10APTPN1 | |
| SCHEMBL268932 | 0.80 | ANO1 (0.43) | CTSSCTSKSCN9ASCN10APTPN1 | |
| SCHEMBL4599931 | 0.80 | LMNA (0.42) | CTSSCTSK | |
| SCHEMBL277941 | 0.80 | ANO1 (0.39) | CTSSCTSKSCN9ASCN10ACYP3A4 | |
| SCHEMBL277955 | 0.79 | CTSS (0.40) | CTSSCTSKSCN9ASCN10ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133907-B2 | Type II diabetes, obesity, hyperglycemia and a lipid disorder selected from dyslipidemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL and high LDL; additionally comprising metformin | ELI LILLY AND COMPANY (US) | 2012-03-13 | — | — | US | disclosed |
| EP-1912946-B1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | LILLY CO ELI (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20080214616-A1 | Pyridine Derivatives as Dipeptedyl Peptidase Inhibitors | ELI LILLY AND COMPANY | 2008-09-04 | — | — | US | disclosed |
| EP-1912946-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | Eli Lilly and Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015767-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214616-A1 | Pyridine Derivatives as Dipeptedyl Peptidase Inhibitors | DPP4, DPP3, DPP7 | CTSS 1680/4885CTSK 2589/4885SCN9A 1412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.