Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 16/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26912305 | 0.89 | ROCK2 (0.38) | ROCK2ROCK1PARP14 | |
| SCHEMBL26913417 | 0.85 | ROCK2 (0.37) | ROCK2ROCK1 | |
| SCHEMBL26912726 | 0.85 | ROCK2 (0.36) | ROCK2ROCK1 | |
| SCHEMBL26912794 | 0.85 | ROCK2 (0.35) | ROCK2ROCK1PARP14 | |
| SCHEMBL26912474 | 0.84 | ROCK2 (0.36) | ROCK2ROCK1AKT1 | |
| SCHEMBL26912388 | 0.83 | ROCK2 (0.36) | ROCK2ROCK1 | |
| SCHEMBL26912382 | 0.83 | ROCK2 (0.36) | ROCK2ROCK1 | |
| SCHEMBL26913261 | 0.83 | ROCK2 (0.36) | ROCK2ROCK1 | |
| SCHEMBL26913088 | 0.81 | ROCK2 (0.35) | ROCK2ROCK1 | |
| SCHEMBL26913068 | 0.79 | AKT2 (0.36) | ROCK2ROCK1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023235809-A1 | CGAS INHIBITORS | ELI LILLY AND COMPANY (US) | 2023-12-07 | — | — | WO | disclosed |
| US-20230391786-A1 | cGAS INHIBITORS | ELI LILLY AND COMPANY | 2023-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230391786-A1 | cGAS INHIBITORS | CGAS, STING1, TBK1 | ROCK2 878/4885ROCK1 824/4885AKT1 1311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.