Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CGAS | Q8N884 | 3/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | STK4 | Q13043 | 1/20 | 0.31 |
| ▸ | STK3 | Q13188 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26912568 | 0.93 | STK3 (0.39) | CGASAKT1ROCK2ROCK1CDC42BPB | |
| SCHEMBL26912394 | 0.88 | CGAS (0.35) | CGASAKT1ROCK2ROCK1CDC42BPB | |
| SCHEMBL26913366 | 0.86 | CGAS (0.36) | CGASROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL26912804 | 0.86 | PGK1 (0.40) | CGASROCK2ROCK1CDC42BPBPIM1 | |
| SCHEMBL26912327 | 0.85 | CGAS (0.38) | CGASAKT1ROCK2ROCK1CDC42BPB | |
| SCHEMBL26912265 | 0.84 | CGAS (0.37) | CGASROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL26912735 | 0.84 | CGAS (0.37) | CGASAKT1ROCK2ROCK1 | |
| SCHEMBL26912150 | 0.84 | CGAS (0.36) | CGASAKT1ROCK2ROCK1LRRK2 | |
| SCHEMBL26912763 | 0.83 | CGAS (0.39) | CGASROCK2ROCK1TDO2 | |
| SCHEMBL26912685 | 0.83 | CGAS (0.35) | CGASROCK2ROCK1CDC42BPBPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023235809-A1 | CGAS INHIBITORS | ELI LILLY AND COMPANY (US) | 2023-12-07 | — | — | WO | disclosed |
| US-20230391786-A1 | cGAS INHIBITORS | ELI LILLY AND COMPANY | 2023-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230391786-A1 | cGAS INHIBITORS | CGAS, STING1, TBK1 | CGAS 1/4885AKT1 1311/4885ROCK2 878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.