Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26912618 | 0.85 | AURKA (0.38) | AURKAAURKBINCENPTPX2MAPK8 | |
| SCHEMBL26912416 | 0.81 | AURKA (0.36) | AURKAAURKBINCENPTPX2MAPK8 | |
| SCHEMBL29410710 | 0.79 | MAPT (0.38) | CSNK2A2CSNK2BCSNK2A1AKT1AKT2 | |
| SCHEMBL25425305 | 0.79 | MAPT (0.38) | CSNK2A2CSNK2BCSNK2A1AKT1AKT2 | |
| SCHEMBL26913053 | 0.73 | CGAS (0.38) | AURKAAURKBINCENPTPX2MAPK8 | |
| SCHEMBL26698252 | 0.72 | IMPDH2 (0.63) | AURKAAURKBINCENPTPX2MAPK8 | |
| SCHEMBL16474984 | 0.72 | AURKA (0.50) | AURKAAURKBINCENPTPX2MAPK8 | |
| SCHEMBL25425205 | 0.72 | AURKA (0.35) | AURKAAURKBINCENPTPX2MAPK8 | |
| Hydrochloric Acid SCHEMBL30684488 | 0.72 | CGAS (0.38) | AURKAAURKBINCENPTPX2MAPK8 | |
| Hydrochloric Acid SCHEMBL26912742 | 0.72 | CGAS (0.38) | AURKAAURKBINCENPTPX2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230391786-A1 | cGAS INHIBITORS | ELI LILLY AND COMPANY | 2023-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230391786-A1 | cGAS INHIBITORS | CGAS, STING1, TBK1 | CSNK2A2 220/4885CSNK2B 199/4885CSNK2A1 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.