Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26922835 | 1.00 | TAAR1 (0.41) | TAAR1HDAC4HDAC8KIF11CYP3A4 | |
| SCHEMBL26922368 | 1.00 | TAAR1 (0.41) | TAAR1HDAC4HDAC8KIF11CYP3A4 | |
| SCHEMBL11073159 | 0.90 | TAAR1 (0.45) | TAAR1HDAC4HDAC8KIF11CYP3A4 | |
| SCHEMBL21610468 | 0.83 | KIF11 (0.40) | TAAR1HDAC4HDAC8KIF11CYP3A4 | |
| SCHEMBL21610470 | 0.83 | KIF11 (0.40) | TAAR1HDAC4HDAC8KIF11CYP3A4 | |
| SCHEMBL27715706 | 0.82 | AOC3 (0.44) | TAAR1TDP1HTR2AGABBR2GABBR1 | |
| SCHEMBL11084835 | 0.80 | SLC6A3 (0.42) | TAAR1HDAC4HDAC8KIF11CYP3A4 | |
| SCHEMBL26947352 | 0.79 | AOC3 (0.44) | TAAR1ALDH1A1GABBR2GABBR1NOS3 | |
| SCHEMBL5775168 | 0.79 | IDO1 (0.42) | TAAR1ALDH1A1CA1CA2MAPT | |
| SCHEMBL9883145 | 0.79 | SLC6A2 (0.46) | TAAR1HDAC4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4316504-A2 | COMPOUNDS | Spero Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| EP-3810633-B1 | COMPOUNDS | SPERO THERAPEUTICS INC (US) | 2023-12-13 | — | — | EP | disclosed |